Mani leads the “Microbiome Systems Biology” research group at the University of Copenhagen. He has an interdisciplinary education with degrees in biotechnology and computer science. His group investigates how our health and diseases are influenced by our gut microbiome; how the gut microbiome interacts with the host and environmental factors; and how we can therapeutically modulate the gut microbiome to improve health. They employ novel data science approaches on host-microbiome multi-omics data.